circRNA basic information
circBase ID: hsa_circ_0000479
Name: hsa_circ_EPSTI1
Synonym: circEPSTI1
Host Gene: EPSTI1
Genomic location(hg19): chr13:43528083-43544806:-
Genomic location(hg38): chr13:42953947-42970670:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0100096
MONDO name: COVID-19
Disease details: COVID-19 / coronavirus disease 2019
Disease DO ID:
 0080600
Disease MeSH ID:
 D000086382
Disease NCIt ID:
 -
Disease ICD11 ID:
 1730556128
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

peripheral blood mononuclear cells (PBMC)
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: RIG-I, IL-6
Associated microRNA: hsa-miR-149-5p
Biological function: modulates immune response; may regulate IL-6 and RIG-I expression
Molecular mechanism: ceRNA mechanism (miRNA sponging of hsa-miR-149-5p) affecting IL-6 and RIG-I
Biological pathway or process:

PI3K/AKT (other); JAK/STAT (other); immune regulation (other); ceRNA regulation (other)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis
Clinical significance:

-
Description:

In PBMCs from COVID-19 patients, hsa_circ_0000479 (circEPSTI1) is up-regulated and negatively correlated with hsa-miR-149-5p. The study proposes a ceRNA axis where hsa_circ_0000479 sponges hsa-miR-149-5p to associate with higher IL-6 and RIG-I expression, with pathway relevance to PI3K-AKT and STAT3 signaling.
Confidence score:

0.348
Other information
Title:

Hsa_circ_0000479/Hsa-miR-149-5p/RIG-I, IL-6 Axis: A Potential Novel Pathway to Regulate Immune Response against COVID-19.

Journal: The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale
Published: 2022
PubMed ID: 36081604
Study type:

combined biological and clinical study
Data availability: The data used to support the findings of this study can be obtained from the corresponding author upon request.
Code availability: -