circRNA basic information
circBase ID: -
Name: hsa_circ_GCLM
Synonym: hsa_circRNA_100283 / circGCLM
Host Gene: GCLM
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0008661
MONDO name: vitiligo
Disease details: vitiligo
Disease DO ID:
 12306
Disease MeSH ID:
 D014820
Disease NCIt ID:
 C26915
Disease ICD11 ID:
 1894744640
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

peripheral blood
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: GCLM
Associated microRNA: hsa-miR-576-5p, hsa-miR-383-5p
Biological function: Associated with ferroptosis in vitiligo treatment response, showing downregulation after systemic glucocorticoid therapy.
Molecular mechanism: Predicted binding to miRNAs (TargetScan/miRanda) as part of annotated circRNA/miRNA interactions for ferroptosis-related DEcircRNAs.
Biological pathway or process:

ferroptosis (other); ceRNA regulation (other)
Detected method:
M
Validation methods:

Microarray; RNase R Treatment; Bioinformatics Analysis
Clinical significance:

-
Description:

circGCLM (hsa_circRNA_100283) was identified as a ferroptosis-associated DEcircRNA that is down-regulated in peripheral blood after methylprednisolone treatment in vitiligo patients. Predicted miRNA binding partners include hsa-miR-576-5p and hsa-miR-383-5p, based on TargetScan/miRanda annotation.
Confidence score:

0.329
Other information
Title:

Differentially Expressed Circular RNAs and Their Therapeutic Mechanism in Non-segmental Vitiligo Patients Treated With Methylprednisolone.

Journal: Frontiers in medicine
Published: 2022
PubMed ID: 35652072
Study type:

combined biological and clinical study
Data availability: GSE197415
Code availability: -