| Expression pattern: |
UP |
| Associated gene: |
DKC1, AGO2 |
| Associated microRNA: |
miR-197-3p |
| Biological function: |
promotes malignant progression (colony formation, proliferation, cell cycle progression, migration/invasion) and oxaliplatin resistance; inhibits apoptosis |
| Molecular mechanism: |
ceRNA mechanism: circ-FLI1 sponges miR-197-3p to regulate DKC1 |
| Biological pathway or process: |
proliferation (promotes); cell cycle (promotes); apoptosis (inhibits); migration (promotes); invasion (promotes); chemoresistance (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; Survival Analysis; Bioinformatics Analysis; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Transfection; Colony Formation Assay; MTT; Cell Cycle Assay; Annexin V/PI Flow Cytometry; Transwell Assay; Western Blot; In Vivo Animal Model |
| Clinical significance: |
High circ-FLI1 was negatively correlated with overall survival and correlated with tumor size, TNM stage, and distant metastasis in 56 CC patients. |
| Description: |
circ-FLI1 (hsa_circ_0000370), derived from FLI1, is up-regulated in colon carcinoma tissues and cell lines and is mainly localized in the cytoplasm. It promotes malignant phenotypes and oxaliplatin resistance by acting as a ceRNA that sponges miR-197-3p, thereby relieving repression of DKC1. High circ-FLI1 is associated with unfavorable overall survival and more advanced clinicopathological features. |
| Confidence score: |
0.8175 |