| Expression pattern: |
UP |
| Associated gene: |
AGK, Ago2 |
| Associated microRNA: |
miR-153-3p |
| Biological function: |
Promotes OSCC cell proliferation, migration, invasion, tube formation and glycolysis, and inhibits apoptosis; promotes tumor growth in vivo. |
| Molecular mechanism: |
Acts as a miRNA sponge for miR-153-3p to regulate its target AGK (ceRNA axis). |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); angiogenesis (promotes); glycolysis (promotes); apoptosis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Nuclear-Cytoplasmic Fractionation; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Transfection; CCK8; EdU Staining; Transwell Assay; Tube Formation Assay; Annexin V/PI Flow Cytometry; Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry); H&E Staining; Clinical Sample Validation; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
circ_0008068 expression was significantly correlated with lymph node metastasis, TNM stage, tumor size and histology grade; higher in the low-overall survival group. |
| Description: |
circ_0008068 is up-regulated in OSCC tissues and cell lines and mainly localizes to the cytoplasm. It promotes OSCC malignant phenotypes and glycolysis and inhibits apoptosis by sponging miR-153-3p to increase AGK expression, and its knockdown suppresses xenograft tumor growth. |
| Confidence score: |
0.8354 |