| Expression pattern: |
DN |
| Associated gene: |
GPX4 |
| Associated microRNA: |
miR-214-3p |
| Biological function: |
circ_0010074 acts as an anti-ferroptotic ceRNA in CVB3-infected OSCC cells; its overexpression preserves cell viability, attenuates CVB3 infection, and counteracts CVB3-induced ferroptosis by maintaining GPX4 expression. |
| Molecular mechanism: |
circ_0010074 functions as a molecular sponge for miR-214-3p, relieving miR-214-3p-mediated suppression of GPX4; CVB3 downregulates circ_0010074, thereby increasing miR-214-3p activity, reducing GPX4, and inducing ferroptosis. |
| Biological pathway or process: |
ferroptosis (inhibits); ceRNA regulation (other); proliferation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Sanger Sequencing; RT-qPCR; FISH / smFISH; Luciferase Reporter Assay; Transfection; CCK8; Western Blot; IF (Immunofluorescence); In Vivo Animal Model; Bioinformatics Analysis |
| Clinical significance: |
- |
| Description: |
In OSCC models, CVB3 downregulates hsa_circ_0010074/circ_0010074, which releases miR-214-3p to suppress GPX4 and promote ferroptosis. circ_0010074 itself functions as a cytoplasmic miR-214-3p sponge and has an anti-ferroptotic, cell-preserving role by sustaining GPX4 expression. |
| Confidence score: |
0.7435 |