circRNA basic information
circBase ID: hsa_circ_0015286
Name: -
Synonym: -
Host Gene: -
Genomic location(hg19): chr1:173833038-173833644:-
Genomic location(hg38): chr1:173863900-173864506:-
Subcellular localization: exosome
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0001056
MONDO name: gastric cancer
Disease details: gastric cancer / GC
Disease DO ID:
 10534
Disease MeSH ID:
 -
Disease NCIt ID:
 C9331
Disease ICD11 ID:
 1397617262
Disease OMIM ID:
 613659
Species: Human
Species details: Homo sapiens
Tissue specimen:

plasma exosomes; GC tissue; paracancerous tissue
Cell lines:

GES-1; BGC823; SGC7901; MGC803; AGS
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: May be involved in the progression of gastric cancer and reflects tumor burden (decreases after surgery).
Molecular mechanism: -
Biological pathway or process:

not specified
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; Clinical Sample Validation; ROC Analysis; Survival Analysis
Clinical significance:

Potential diagnostic biomarker (ROC AUC 0.778; combined with CEA and CA 19-9 AUC 0.843/0.833) and prognostic biomarker (high expression associated with shorter overall survival); decreases after surgery.
Description:

Plasma exosomal hsa_circ_0015286 is significantly up-regulated in gastric cancer and correlates with tumor size, T stage and lymph node metastasis. It shows diagnostic value by ROC analysis and has prognostic relevance, where higher expression is associated with poorer overall survival; its level decreases after surgery, suggesting association with tumor burden.
Confidence score:

0.5202
Other information
Title:

Plasma Exosomal hsa_circ_0015286 as a Potential Diagnostic and Prognostic Biomarker for Gastric Cancer.

Journal: Pathology oncology research : POR
Published: 2022
PubMed ID: 35755416
Study type:

combined biological and clinical study
Data availability: GSE202538
Code availability: -