circRNA basic information
circBase ID: hsa_circ_0000375
Name: hsa_circ_IFFO1
Synonym: circ_0000375
Host Gene: IFFO1
Genomic location(hg19): chr12:6657590-6657991:-
Genomic location(hg38): chr12:6548424-6548825:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005575
MONDO name: colorectal cancer
Disease details: colorectal cancer / CRC
Disease DO ID:
 5672, 9256
Disease MeSH ID:
 -
Disease NCIt ID:
 C4978
Disease ICD11 ID:
 -
Disease OMIM ID:
 114500
Species: Human
Species details: Homo sapiens
Tissue specimen:

tumor tissue; colon tissue; serum
Cell lines:

HCT; RKO; SW480; HCT116; FHC; HEK293T
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: -
Associated microRNA: miR-1182
Biological function: Suppresses colorectal cancer cell proliferation, migration and invasion; potential diagnostic biomarker
Molecular mechanism: Acts as a miRNA sponge for miR-1182 (ceRNA-like interaction) verified by luciferase reporter assay
Biological pathway or process:

proliferation (inhibits); migration (inhibits); invasion (inhibits); ceRNA regulation (promotes); Wnt/beta-catenin (other)
Detected method:
Q
M
Validation methods:

Bioinformatics Analysis; Microarray; RT-qPCR; Sanger Sequencing; RNase R Treatment; Luciferase Reporter Assay; Transfection; CCK8; Wound Healing Assay; Transwell Assay; ROC Analysis; Clinical Sample Validation
Clinical significance:

Diagnostic biomarker in CRC tissue and serum with high AUC; serum levels increased after surgery compared with preoperative patients
Description:

hsa_circ_0000375 (circ_0000375) is down-regulated in colorectal cancer tissues, serum, and CRC cell lines and shows strong diagnostic performance. Functionally, its overexpression suppresses CRC cell proliferation, migration, and invasion, and it acts as a miRNA sponge for miR-1182 as supported by luciferase assays.
Confidence score:

0.814
Other information
Title:

Identification of circ_0000375 and circ_0011536 as novel diagnostic biomarkers of colorectal cancer.

Journal: World journal of clinical cases
Published: 2022
PubMed ID: 35611198
Study type:

combined biological and clinical study
Data availability: GSE126095; GSE41655; GSE49246; GSE115513
Code availability: -