| Expression pattern: |
DN |
| Associated gene: |
TIMP2, AGO2, Wnt5a, beta-catenin, E-cadherin, Vimentin, VEGF, Ki-67, IL-10 |
| Associated microRNA: |
miR-106a / hsa-miR-106a-5p |
| Biological function: |
circTIMP2 suppresses gastric cancer cell proliferation, migration, invasion, angiogenesis, EMT, Wnt/beta-catenin signaling and tumor growth, while promoting apoptosis; tumor-derived exosomes counteract its tumor-suppressive effects. |
| Molecular mechanism: |
circTIMP2 acts as a ceRNA sponge for miR-106a, relieving repression of TIMP2 and forming a circTIMP2/miR-106a/TIMP2 feedback loop that inhibits Wnt/beta-catenin signaling and EMT; tumor-derived exosomes disrupt this protective loop. |
| Biological pathway or process: |
ceRNA regulation (promotes); Wnt/beta-catenin (inhibits); EMT (inhibits); proliferation (inhibits); apoptosis (promotes); migration (inhibits); invasion (inhibits); angiogenesis (inhibits); metastasis (inhibits); immune regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; RT-qPCR; FISH / smFISH; Clinical Sample Validation; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Transfection; EdU Staining; Colony Formation Assay; Annexin V/PI Flow Cytometry; Transwell Assay; Wound Healing Assay; TUNEL; In Vivo Animal Model; H&E Staining; ELISA; Western Blot; IHC (Immunohistochemistry); Bioinformatics Analysis |
| Clinical significance: |
circTIMP2 is significantly downregulated in human gastric cancer tissues and is highlighted as a promising therapeutic target; no diagnostic or prognostic survival association was reported. |
| Description: |
circTIMP2 is downregulated in gastric cancer and functions as a tumor suppressor. It sponges miR-106a to relieve repression of TIMP2, thereby inhibiting Wnt/beta-catenin signaling, EMT, proliferation, migration, invasion, angiogenesis and tumor growth while promoting apoptosis. Tumor-derived exosomes can counteract this protective circTIMP2/miR-106a/TIMP2 axis and promote tumor progression. |
| Confidence score: |
0.8175 |