| Expression pattern: |
UP |
| Associated gene: |
PBX3, AGO2 |
| Associated microRNA: |
miR-1294 |
| Biological function: |
promotes GC cell proliferation, migration, invasion, angiogenesis and glutaminolysis; inhibits apoptosis; promotes tumor growth in vivo |
| Molecular mechanism: |
ceRNA/sponging: hsa_circ_0043691 binds miR-1294 to modulate PBX3 expression |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); angiogenesis (promotes); apoptosis (inhibits); glutaminolysis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; Transfection; Colony Formation Assay; Wound Healing Assay; Transwell Assay; Annexin V/PI Flow Cytometry; Tube Formation Assay; Western Blot; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); RNA Pull-Down; In Vivo Animal Model; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
high hsa_circ_0043691 expression was associated with advanced stage, lymph node metastasis, larger tumor size, and shorter survival in GC patients |
| Description: |
hsa_circ_0043691 is up-regulated in gastric cancer tissues and cell lines and is mainly localized in the cytoplasm. It promotes malignant phenotypes (proliferation, migration/invasion, angiogenesis), enhances glutaminolysis, and supports tumor growth by sponging miR-1294 to upregulate PBX3. |
| Confidence score: |
0.8689 |