| Expression pattern: |
DN |
| Associated gene: |
KLF14 |
| Associated microRNA: |
miR-374a-3p |
| Biological function: |
Suppresses CRC progression by inhibiting tumor growth, cell cycle and glycolysis, and promoting apoptosis. |
| Molecular mechanism: |
Acts as a ceRNA sponge for miR-374a-3p to up-regulate KLF14. |
| Biological pathway or process: |
glycolysis (inhibits); cell cycle (inhibits); apoptosis (promotes); ceRNA regulation (other) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; RNase R Treatment; Nuclear-Cytoplasmic Fractionation; Bioinformatics Analysis; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Transfection; Cell Cycle Assay; Annexin V/PI Flow Cytometry; Western Blot; In Vivo Animal Model |
| Clinical significance: |
CircTADA2A expression was negatively correlated with the tumor size, pT stage and distant metastasis of CRC tumors; proposed as a biomarker/target for CRC treatment. |
| Description: |
CircTADA2A is down-regulated in colorectal cancer and mainly localized in the cytoplasm. It suppresses CRC progression by sponging miR-374a-3p to up-regulate KLF14, thereby inhibiting cell cycle progression and glycolysis and promoting apoptosis, and it reduces tumor growth in xenograft models. |
| Confidence score: |
0.7328 |