| Expression pattern: |
UP |
| Associated gene: |
CREBRF |
| Associated microRNA: |
miR-1305 |
| Biological function: |
Promotes cervical cancer cell proliferation, migration, invasion, angiogenesis, EMT and tumor growth; inhibits apoptosis. |
| Molecular mechanism: |
circ_0009035 acts through a ceRNA-like mechanism by targeting miR-1305 and regulating CREBRF expression. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); angiogenesis (promotes); apoptosis (inhibits); EMT (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RNase R Treatment; RT-qPCR; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Transfection; CCK8; EdU Staining; Colony Formation Assay; Annexin V/PI Flow Cytometry; Transwell Assay; Tube Formation Assay; Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry); Bioinformatics Analysis |
| Clinical significance: |
circ_0009035 was upregulated in cervical cancer tissues and higher in stage III than in stage I and II. |
| Description: |
circ_0009035/circRACGAP1 is upregulated in cervical cancer tissues and cell lines and is mainly localized in the cytoplasm. Functional knockdown experiments indicate that it promotes proliferation, migration, invasion, angiogenesis, EMT and xenograft tumor growth while suppressing apoptosis. Mechanistically, circ_0009035 targets miR-1305 to regulate CREBRF expression, forming a circ_0009035/miR-1305/CREBRF axis in cervical cancer progression. |
| Confidence score: |
0.8175 |