circRNA basic information
circBase ID: hsa_circ_0003000
Name: hsa_circ_ORC5
Synonym: -
Host Gene: ORC5
Genomic location(hg19): chr7:103828698-103844682:-
Genomic location(hg38): chr7:104188250-104204234:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0011122
MONDO name: obesity disorder
Disease details: obesity
Disease DO ID:
 9970
Disease MeSH ID:
 -
Disease NCIt ID:
 C3283
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

visceral adipose tissue / VAT
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: TNFRSF10D, XCR1, CARD11
Associated microRNA: miR-1226-3p, miR-197-5p, miR-6780-5p, miR-6780a-5p
Biological function: Regulates an obesity-associated inflammation-related ceRNA network in visceral adipose tissue.
Molecular mechanism: ceRNA mechanism involving miRNA sponging and regulation of inflammation-related target genes including TNFRSF10D, CARD11 and XCR1.
Biological pathway or process:

ceRNA regulation (other); inflammation (other); NF-kappaB (other); other pathway/process (other)
Detected method:
Q
S
Validation methods:

circRNA-seq; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; RNA-seq
Clinical significance:

Potential biomarker of obesity.
Description:

hsa_circ_0003000, named circORC5, is down-regulated in visceral adipose tissue from obese individuals. The study proposes that circORC5 participates in an inflammation-related ceRNA network, including circORC5/miR-197-5p/TNFRSF10D and additional predicted miRNA-target interactions involving miR-1226-3p, miR-6780a-5p, XCR1 and CARD11.
Confidence score:

0.5135
Other information
Title:

Transcriptome of visceral adipose tissue identifies an inflammation-related ceRNA network that regulates obesity.

Journal: Molecular and cellular biochemistry
Published: 2022
PubMed ID: 35064875
Study type:

combined bioinformatics and clinical study
Data availability: PRJNA763819
Code availability: -