| Expression pattern: |
UP |
| Associated gene: |
METTL3 |
| Associated microRNA: |
miR-590-5p |
| Biological function: |
promotes proliferation, inhibits apoptosis, and accelerates cell cycle progression of colorectal cancer cells |
| Molecular mechanism: |
ceRNA mechanism: circ_0001658 sponges miR-590-5p to upregulate METTL3 |
| Biological pathway or process: |
proliferation (promotes); apoptosis (inhibits); cell cycle (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; RNase R Treatment; Nuclear-Cytoplasmic Fractionation; Luciferase Reporter Assay; Bioinformatics Analysis; Transfection; CCK8; Cell Cycle Assay; Annexin V/PI Flow Cytometry; Western Blot; Clinical Sample Validation |
| Clinical significance: |
- |
| Description: |
In colorectal cancer, circ_0001658 is up-regulated in tissues and CRC cell lines and acts as an oncogenic circRNA. It mainly localizes to the cytoplasm and promotes proliferation and cell-cycle progression while inhibiting apoptosis by sponging miR-590-5p to increase METTL3 expression. |
| Confidence score: |
0.7519 |