| Expression pattern: |
DN |
| Associated gene: |
TESC |
| Associated microRNA: |
hsa-miR-330-5p, hsa-miR-498, hsa-miR-532-3p, hsa-miR-577, hsa-miR-1248, hsa-miR-1305 |
| Biological function: |
Potential tumor suppressor; low expression is associated with tumor invasion, advanced clinical stage, and worse OS/PFS in HNC. |
| Molecular mechanism: |
Predicted ceRNA mechanism: hsa_circ_0001675 may sponge six miRNAs and regulate downstream mRNAs; likely involves the hsa_circ_0001675/miR577/TESC axis (predicted; partially supported by TESC IHC). |
| Biological pathway or process: |
ceRNA regulation (other); cAMP (other); calcium signaling (other); neuroactive ligand-receptor interaction (other); invasion (inhibits) |
| Detected method: |
Q
S
|
| Validation methods: |
RNA-seq; RT-qPCR; Clinical Sample Validation; ROC Analysis; Survival Analysis; Bioinformatics Analysis; IHC (Immunohistochemistry) |
| Clinical significance: |
Downregulated in HNC; diagnostic value (AUC=0.7776); low expression correlates with OS and PFS; independent prognostic factor. |
| Description: |
hsa_circ_0001675 is significantly downregulated in head and neck cancer tissues and its low expression is associated with more advanced disease and worse patient survival. The study proposes that hsa_circ_0001675 may function as a tumor suppressor via a predicted ceRNA network, with a likely downstream hsa_circ_0001675/miR-577/TESC axis, supported indirectly by reduced TESC protein staining in tumors. |
| Confidence score: |
0.5734 |