circRNA basic information
circBase ID: hsa_circ_0034326
Name: -
Synonym: -
Host Gene: -
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007256
MONDO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Disease DO ID:
 684, 686
Disease MeSH ID:
 D006528
Disease NCIt ID:
 C3099
Disease ICD11 ID:
 1294035808
Disease OMIM ID:
 114550
Species: Human
Species details: Homo sapiens
Tissue specimen:

HCC tissues samples; normal tissues samples
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DS
Associated gene: ITGA5, SLC12A5, NRAS
Associated microRNA: miR-25-3p, miR-4270
Biological function: Might function as a ceRNA and play key roles in HCC by sponging miR-25-3p and miR-4270 and regulating gene expression.
Molecular mechanism: ceRNA mechanism; hsa-circ-0034326 may sponge miR-25-3p and miR-4270 to regulate ITGA5, SLC12A5, and NRAS in HCC.
Biological pathway or process:

ceRNA regulation (other); other pathway/process (other)
Detected method:
M
Validation methods:

Microarray; Bioinformatics Analysis
Clinical significance:

May provide novel insight into pathogenesis, selection of therapeutic targets and prognostic factors for HCC.
Description:

hsa-circ-0034326 was identified by microarray-based bioinformatics analysis as a dysregulated circRNA in HCC and a hub circRNA in a circRNA-miRNA-mRNA regulatory network. The study predicted that it may act as a ceRNA by sponging miR-25-3p and miR-4270, regulating ITGA5, SLC12A5, and NRAS-related axes in HCC, but no experimental validation was performed.
Confidence score:

0.1768
Other information
Title:

Identification and analysis of circRNA-miRNA-mRNA regulatory network in hepatocellular carcinoma.

Journal: IET systems biology
Published: 2020
PubMed ID: 33399102
Study type:

bioinformatics study
Data availability: GSE97332; GSE57555; TCGA-LIHC; DGIdb
Code availability: -