| Expression pattern: |
UP |
| Associated gene: |
ROCK2, Ago2 |
| Associated microRNA: |
miR-3619-5p |
| Biological function: |
Facilitates M2 macrophage-induced angiogenesis and tube formation; promotes endothelial cell migration and invasion. |
| Molecular mechanism: |
Acts as a miRNA sponge for miR-3619-5p to upregulate ROCK2 and activate ROCK signaling, promoting angiogenesis. |
| Biological pathway or process: |
angiogenesis (promotes); migration (promotes); invasion (promotes); ROCK signaling (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Transfection; Wound Healing Assay; Transwell Assay; Tube Formation Assay; Western Blot; IHC (Immunohistochemistry) |
| Clinical significance: |
- |
| Description: |
circ_TNFRSF21 is up-regulated in cSCC tissues and elevated in M2 macrophages/TAMs. It promotes M2 macrophage-induced angiogenesis (endothelial migration, invasion, and tube formation) by sponging miR-3619-5p, thereby releasing ROCK2/ROCK signaling activity. |
| Confidence score: |
0.7537 |