| Expression pattern: |
DN |
| Associated gene: |
QKI |
| Associated microRNA: |
miR-1264 |
| Biological function: |
circ1322 inhibits gastric cancer cell proliferation, migration, invasion and tumor growth, while promoting apoptosis. |
| Molecular mechanism: |
circ1322 acts as a competing endogenous RNA sponge for miR-1264, relieves miR-1264-mediated inhibition of QKI, and suppresses the Hedgehog pathway. |
| Biological pathway or process: |
Hedgehog (inhibits); proliferation (inhibits); migration (inhibits); invasion (inhibits); apoptosis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Transfection; CCK8; Colony Formation Assay; Annexin V/PI Flow Cytometry; Transwell Assay; In Vivo Animal Model; Western Blot |
| Clinical significance: |
Low expression of circ_0001322 was negatively correlated with lymph node metastasis, showed diagnostic potential for GC metastasis, and hsa_circ_0001322 may serve as a biomarker for predicting GC prognosis. |
| Description: |
hsa_circ_0001322/circ1322 is down-regulated in gastric cancer tissues and cell lines. Its upregulation suppresses GC proliferation, migration, invasion and xenograft tumor growth while promoting apoptosis. Mechanistically, circ1322 functions as a ceRNA sponge for miR-1264, increases QKI expression, and suppresses Hedgehog pathway activity, suggesting potential biomarker value in GC. |
| Confidence score: |
0.7595 |