| Expression pattern: |
UP |
| Associated gene: |
PODXL, CEBPB |
| Associated microRNA: |
hsa-miR-4269 |
| Biological function: |
Potential oncogene candidate involved in gastric cancer; high expression is associated with invasion and shorter survival; may affect tumorigenesis by acting as competing RNA for hsa-miR-4269 and regulating PODXL. |
| Molecular mechanism: |
hsa_circ_0058092 may act as a competing endogenous RNA for hsa-miR-4269 and influence PODXL expression; CEBPB was predicted as a potential transcription factor regulating hsa_circ_0058092. |
| Biological pathway or process: |
ceRNA regulation (promotes); invasion (promotes); PI3K/AKT (other); other pathway/process (other) |
| Detected method: |
Q
S
|
| Validation methods: |
RT-qPCR; RNA-seq; Clinical Sample Validation; IHC (Immunohistochemistry); Western Blot; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
High expression was significantly associated with degree of invasion in gastric cancer and shorter survival time. |
| Description: |
hsa_circ_0058092 is an up-regulated circRNA in gastric cancer and was selected as a potential oncogene candidate. The study suggests that it may act as a ceRNA for hsa-miR-4269 to influence PODXL, and its high expression is associated with invasion and poorer patient survival. |
| Confidence score: |
0.6257 |