| Expression pattern: |
DN |
| Associated gene: |
MEIS2, Ago2 |
| Associated microRNA: |
miR-421 |
| Biological function: |
inhibits prostate cancer cell proliferation, migration, invasion and metastasis |
| Molecular mechanism: |
circDHRS3 acts as an RNA sponge for miR-421 and thereby modulates MEIS2 expression |
| Biological pathway or process: |
proliferation (inhibits); migration (inhibits); invasion (inhibits); metastasis (inhibits); ceRNA regulation (other) |
| Detected method: |
Q
H
S
|
| Validation methods: |
circRNA-seq; RT-qPCR; Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; RNase R Treatment; Actinomycin D / DRB Stability Assay; ISH (In Situ Hybridization); FISH / smFISH; RIP (RNA Immunoprecipitation); RNA Pull-Down; Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; EdU Staining; Transwell Assay; Wound Healing Assay; Western Blot; In Vivo Animal Model; H&E Staining; Clinical Sample Validation; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
circDHRS3 might be used as a marker to predict prostate cancer prognosis |
| Description: |
circDHRS3 is down-regulated in prostate cancer (especially high Gleason grade) and functions as a tumor suppressor. It sponges miR-421 in the cytoplasm to relieve repression of MEIS2, thereby inhibiting proliferation, migration/invasion, and lung/bone metastasis in vitro and in vivo. |
| Confidence score: |
0.8812 |