| Expression pattern: |
UP |
| Associated gene: |
ABCF2 |
| Associated microRNA: |
miR-4731-5p |
| Biological function: |
enhances sunitinib resistance and promotes proliferation, migration and invasion while inhibiting apoptosis in RCC cells |
| Molecular mechanism: |
acts as a miRNA sponge (ceRNA) for miR-4731-5p to regulate ABCF2 |
| Biological pathway or process: |
drug resistance (promotes); proliferation (promotes); apoptosis (inhibits); migration (promotes); invasion (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; divergent primers PCR; MTT; Colony Formation Assay; Annexin V/PI Flow Cytometry; Transwell Assay; Luciferase Reporter Assay; RNA Pull-Down; Transfection; Western Blot; Clinical Sample Validation; Bioinformatics Analysis |
| Clinical significance: |
increased circEHD2 was implicated in histological grade and sunitinib resistance in RCC patients |
| Description: |
circEHD2 is up-regulated in sunitinib-resistant RCC tissues/cells and promotes sunitinib resistance and malignant phenotypes. Mechanistically, circEHD2 sponges miR-4731-5p to increase ABCF2, and ABCF2 overexpression counteracts the effects of circEHD2 knockdown. |
| Confidence score: |
0.7945 |