circRNA basic information
circBase ID: -
Name: hsa_circ_RNF138
Synonym: circRNF138
Host Gene: RNF138
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: extracellular vesicle
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005575
MONDO name: colorectal cancer
Disease details: colorectal cancer
Disease DO ID:
 5672, 9256
Disease MeSH ID:
 -
Disease NCIt ID:
 C4978
Disease ICD11 ID:
 -
Disease OMIM ID:
 114500
Species: Human
Species details: Homo sapiens
Tissue specimen:

human bile; bile EV samples
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: Potential marker used to distinguish malignant cancers from benign biliary diseases.
Molecular mechanism: -
Biological pathway or process:

not specified
Detected method:
S
Validation methods:

RNA-seq; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis
Clinical significance:

Potential marker used to distinguish malignant cancers from benign biliary diseases.
Description:

circRNF138 was one of six bile EV circRNAs reported as enriched in malignant cancer samples. It was proposed as a potential diagnostic biomarker, but the article did not report RT-qPCR validation or functional mechanistic assays specifically for circRNF138.
Confidence score:

0.459
Other information
Title:

Extracellular vesicles long RNA profiling identifies abundant mRNA, circRNA and lncRNA in human bile as potential biomarkers for cancer diagnosis.

Journal: Carcinogenesis
Published: 2023
PubMed ID: 37696683
Study type:

combined clinical and bioinformatics study
Data availability: The data used to support the findings of this study are available from the corresponding author upon request.
Code availability: -