| Expression pattern: |
UP |
| Associated gene: |
KLF12 |
| Associated microRNA: |
miR-138-5p |
| Biological function: |
promotes proliferation, migration, invasion and EMT; inhibits apoptosis; promotes tumor growth |
| Molecular mechanism: |
circ_CORO1C sponges miR-138-5p to positively regulate KLF12 expression (ceRNA mechanism). |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); EMT (promotes); apoptosis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; divergent primers PCR; Transfection; Colony Formation Assay; MTT; Transwell Assay; Annexin V/PI Flow Cytometry; Western Blot; Luciferase Reporter Assay; In Vivo Animal Model; Clinical Sample Validation |
| Clinical significance: |
- |
| Description: |
circ_CORO1C is up-regulated in gastric cancer tissues and cell lines and functions as an oncogenic circRNA. Its knockdown suppresses proliferation, migration, invasion and EMT while promoting apoptosis, and inhibits tumor growth in a xenograft model by sponging miR-138-5p to upregulate KLF12. |
| Confidence score: |
0.7416 |