circRNA basic information
circBase ID: hsa_circ_0000337
Name: hsa_circ_PPFIA1
Synonym: hsa_circRNA_100872
Host Gene: PPFIA1
Genomic location(hg19): chr11:70200406-70202360:+
Genomic location(hg38): chr11:70354300-70356254:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005580
MONDO name: esophageal squamous cell carcinoma
Disease details: esophageal squamous cell carcinoma
Disease DO ID:
 3748
Disease MeSH ID:
 C562729; D000077277
Disease NCIt ID:
 C4024
Disease ICD11 ID:
 1417891145
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

cancer tissues; adjacent normal-appearing tissues
Cell lines:

KYSE-150; TE-1; HET-1A
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: GJB7, PCTP, STX6, FAM174B, PPP2CA, TOR2A, YOD1, ZSWIM6, UBR7, PROX1, SEMA4B, DHX33, PPP1R37, PLXDC1, ANAPC16, ZNF385A, SP1, SH3BP5L, MKNK2, SEMA4C, EHD1
Associated microRNA: miR-670-5p
Biological function: promotes cell proliferation, migration, and invasion
Molecular mechanism: Acts as a miRNA sponge binding miR-670-5p; predicted circRNA-miRNA-mRNA axis regulating downstream targets.
Biological pathway or process:

proliferation (promotes); migration (promotes); invasion (promotes); ceRNA regulation (other)
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; Transwell Assay; Wound Healing Assay
Clinical significance:

This circRNA could be a promising diagnostic biomarker and potential therapeutic target.
Description:

hsa_circ_0000337 is up-regulated in ESCC tissues and promotes ESCC cell proliferation, migration, and invasion. Mechanistically, it functions as a miRNA sponge for miR-670-5p, supporting a circRNA-miRNA-mRNA regulatory axis with predicted downstream targets.
Confidence score:

0.6815
Other information
Title:

Upregulated circ RNA hsa_circ_0000337 promotes cell proliferation, migration, and invasion of esophageal squamous cell carcinoma.

Journal: Cancer management and research
Published: 2019
PubMed ID: 30881124
Study type:

combined biological and clinical study
Data availability: -
Code availability: -