| Expression pattern: |
UP |
| Associated gene: |
CYP1A2, METTL3 |
| Associated microRNA: |
miR-182-5p |
| Biological function: |
promotes proliferation, migration and invasion; promotes tumor growth |
| Molecular mechanism: |
METTL3-dependent m6A methylation increases circ_0008345 expression/stability; circ_0008345 acts as a ceRNA sponging miR-182-5p to relieve repression of CYP1A2 |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); metastasis (other); ceRNA regulation (promotes); m6A modification (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; Nuclear-Cytoplasmic Fractionation; RNA Pull-Down; Luciferase Reporter Assay; Transfection; Colony Formation Assay; EdU Staining; Transwell Assay; In Vivo Animal Model; MeRIP / MeRIP-seq; Bioinformatics Analysis; Clinical Sample Validation |
| Clinical significance: |
- |
| Description: |
circ_0008345 is up-regulated in colorectal cancer and mainly localized in the cytoplasm. It promotes CRC proliferation, migration/invasion and xenograft tumor growth by acting as a ceRNA that sponges miR-182-5p to increase CYP1A2. METTL3-mediated m6A modification enhances circ_0008345 expression/stability, reinforcing this axis. |
| Confidence score: |
0.8267 |