circRNA basic information
circBase ID: hsa_circ_0000918
Name: hsa_circ_GMIP
Synonym: -
Host Gene: GMIP
Genomic location(hg19): chr19:19750893-19751380:-
Genomic location(hg38): chr19:19640084-19640571:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005140
MONDO name: ovarian carcinoma
Disease details: epithelial ovarian cancer / EOC
Disease DO ID:
 4001
Disease MeSH ID:
 -
Disease NCIt ID:
 C4908
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

primary tumor lesions; tumor cells from ascites; metastatic lesions
Cell lines:

SKOV3; OVCAR3
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: BAIAP2L2, LILRA5, PPP6R2, ANO8, GRIK2, TNFRSF25, CCR7, TNNI2, EPGN, RNF207, KRT5, FFAR2, GDF5, GPR132, MYO1F, PIK3R5, SLC43A2
Associated microRNA: hsa-miR-1202, hsa-miR-1267, hsa-miR-149-5p, hsa-miR-4645-5p, hsa-miR-6071, hsa-miR-6823-5p, hsa-miR-766-3p
Biological function: promotes migration and invasion (metastasis) of EOC cells via EMT in vitro; promotes proliferation
Molecular mechanism: ceRNA network prediction (circRNA sponging miRNAs to regulate downstream mRNAs); EMT marker regulation upon circRNA overexpression/silencing
Biological pathway or process:

EMT (promotes); migration (promotes); invasion (promotes); metastasis (promotes); proliferation (promotes); ceRNA regulation (other)
Detected method:
Q
S
Validation methods:

RNA-seq; RT-qPCR; Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; Clinical Sample Validation; Transfection; Wound Healing Assay; Transwell Assay; Western Blot
Clinical significance:

may serve as novel potential therapeutic targets or prognostic biomarkers for EOC peritoneal metastasis
Description:

In EOC, hsa_circ_0000918 is up-regulated in ascites tumor cells versus primary and metastatic lesions, and it promotes migration/invasion (metastatic traits) by enhancing EMT in vitro. A predicted circRNA-miRNA-mRNA ceRNA network was built to suggest downstream regulatory targets.
Confidence score:

0.7046
Other information
Title:

Hsa_circ_0000497 and hsa_circ_0000918 contributed to peritoneal metastasis of ovarian cancer via ascites.

Journal: Journal of translational medicine
Published: 2022
PubMed ID: 35538537
Study type:

combined biological and clinical study
Data availability: available from the corresponding author on reasonable request
Code availability: -