circRNA basic information
circBase ID: hsa_circ_0000285
Name: hsa_circ_HIPK3
Synonym: circ_0000285
Host Gene: HIPK3
Genomic location(hg19): chr11:33362513-33363232:+
Genomic location(hg38): chr11:33340967-33341686:+
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0001056
MONDO name: gastric cancer
Disease details: Gastric cancer / GC
Disease DO ID:
 10534
Disease MeSH ID:
 -
Disease NCIt ID:
 C9331
Disease ICD11 ID:
 1397617262
Disease OMIM ID:
 613659
Species: Human
Species details: Homo sapiens
Tissue specimen:

GC tissues; normal adjacent tissues
Cell lines:

HGC-27; GTL-16; AGS; GES-1
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: FN1, Ago2
Associated microRNA: miR-1278
Biological function: promotes proliferation and invasion; inhibits apoptosis; promotes tumor development
Molecular mechanism: Acts as a ceRNA by sponging miR-1278, thereby upregulating FN1.
Biological pathway or process:

proliferation (promotes); invasion (promotes); apoptosis (inhibits); ceRNA regulation (promotes)
Detected method:
Q
Validation methods:

RNase R Treatment; RT-qPCR; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; Transfection; CCK8; Transwell Assay; Annexin V/PI Flow Cytometry; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Western Blot; In Vivo Animal Model
Clinical significance:

may serve as a potential therapeutic biomarker for GC
Description:

hsa_circ_0000285 is upregulated in gastric cancer and mainly localized in the cytoplasm. It promotes GC cell proliferation and invasion and inhibits apoptosis by sponging miR-1278, thereby increasing FN1 expression via the hsa_circ_0000285/miR-1278/FN1 ceRNA axis.
Confidence score:

0.7631
Other information
Title:

Hsa_circ_0000285 contributes to gastric cancer progression by upregulating FN1 through the inhibition of miR-1278.

Journal: Journal of clinical laboratory analysis
Published: 2022
PubMed ID: 35535385
Study type:

combined biological and clinical study
Data availability: The datasets that have been used and/or analyzed in this study are available from the corresponding author upon reasonable request.
Code availability: -