| Expression pattern: |
UP |
| Associated gene: |
CDK6 |
| Associated microRNA: |
miR-1263 |
| Biological function: |
Promotes proliferation, tumorigenesis and G1/S transition in HCC. |
| Molecular mechanism: |
Acts as a miRNA sponge (ceRNA) for miR-1263 to increase CDK6 expression, promoting cell-cycle progression (G1/S). |
| Biological pathway or process: |
proliferation (promotes); cell cycle (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Survival Analysis; Nuclear-Cytoplasmic Fractionation; FISH / smFISH; Actinomycin D / DRB Stability Assay; Transfection; CCK8; EdU Staining; Colony Formation Assay; Cell Cycle Assay; RNA Pull-Down; Luciferase Reporter Assay; Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry) |
| Clinical significance: |
Upregulation/high expression of circERBIN predicts poor prognosis (shorter overall survival) and is associated with poorer clinicopathological features (tumor size, Edmondson grade, TNM stage). |
| Description: |
circERBIN is upregulated in HCC and mainly localized in the cytoplasm. It promotes HCC cell proliferation and tumor growth by sponging miR-1263 to increase CDK6 expression and accelerate G1/S transition, and high circERBIN is associated with poorer overall survival. |
| Confidence score: |
0.8309 |