| Expression pattern: |
UP |
| Associated gene: |
MCL1, AGO2 |
| Associated microRNA: |
miR-193a-3p |
| Biological function: |
promotes proliferation, migration, invasion and tumor growth in prostate cancer |
| Molecular mechanism: |
acts as a ceRNA/miRNA sponge for miR-193a-3p to upregulate MCL1 expression |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Nuclear-Cytoplasmic Fractionation; RIP (RNA Immunoprecipitation); RNA Pull-Down; Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; Wound Healing Assay; Transwell Assay; Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry); Clinical Sample Validation; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
higher circHIPK3 expression was associated with tumor stage; increased circHIPK3 levels predict poor prognosis in PCa patients |
| Description: |
circHIPK3 is up-regulated in prostate cancer and functions as an oncogenic circRNA. It mainly localizes to the cytoplasm and sponges miR-193a-3p, thereby increasing MCL1 expression to promote proliferation, migration/invasion, and xenograft tumor growth; higher circHIPK3 levels are associated with advanced tumor stage and poor prognosis. |
| Confidence score: |
0.8146 |