| Expression pattern: |
UP |
| Associated gene: |
androgen receptor (AR), androgen receptor splice variant 7 (AR-V7) |
| Associated microRNA: |
- |
| Biological function: |
Promotes prostate cancer cell proliferation and cell cycle progression; knockdown inhibits DNA synthesis, suppresses proliferation, and causes G1-phase cell cycle arrest. |
| Molecular mechanism: |
circZMIZ1 increases AR and AR-V7 expression; its expression can be induced by DHT and is associated with androgen receptor signaling. |
| Biological pathway or process: |
proliferation (promotes); cell cycle (promotes); other pathway/process (promotes) |
| Detected method: |
Q
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; RT-qPCR; FISH / smFISH; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; Transfection; CCK8; EdU Staining; Cell Cycle Assay |
| Clinical significance: |
circZMIZ1 may serve as a novel diagnostic serum biomarker and treatment target for prostate cancer. |
| Description: |
circZMIZ1 is upregulated in plasma from prostate cancer patients and in prostate cancer cell lines. The study supports an oncogenic role in prostate cancer by promoting cell proliferation and cell cycle progression, and suggests that circZMIZ1 modulates AR and AR-V7 expression in the androgen receptor signaling context. circZMIZ1 may serve as a diagnostic serum biomarker and potential therapeutic target for prostate cancer. |
| Confidence score: |
0.741 |