circRNA basic information
circBase ID: hsa_circ_0001944
Name: -
Synonym: circ_0001944
Host Gene: -
Genomic location(hg19): chrX:130883333-130928494:-
Genomic location(hg38): chrX:131749305-131794466:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005233
MONDO name: non-small cell lung carcinoma
Disease details: non-small cell lung cancer
Disease DO ID:
 3908
Disease MeSH ID:
 D002289
Disease NCIt ID:
 C2926
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

NSCLC tissues; neighbor normal tissues; xenograft tumors
Cell lines:

BEAS-2B; A549; H1975; H522; HCC827; HEK293T
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: NFAT5, HK2, LDHA
Associated microRNA: miR-142-5p
Biological function: promotes proliferation, migration, invasion, glycolysis, and tumor growth in NSCLC
Molecular mechanism: acts as a miRNA sponge/decoy for miR-142-5p to upregulate NFAT5, affecting glycolysis-related proteins (HK2, LDHA)
Biological pathway or process:

glycolysis (promotes); proliferation (promotes); migration (promotes); invasion (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; Transfection; MTT; Colony Formation Assay; Transwell Assay; Western Blot; Luciferase Reporter Assay; RNA Pull-Down; In Vivo Animal Model; Survival Analysis; Bioinformatics Analysis
Clinical significance:

NSCLC patients with high expression of circ_0001944 had a worse prognosis
Description:

circ_0001944 is up-regulated in NSCLC and promotes malignant phenotypes and glycolysis. Mechanistically, it acts as a sponge/decoy for miR-142-5p to relieve repression of NFAT5, leading to increased glycolysis-related markers (HK2, LDHA) and enhanced tumor growth in vitro and in vivo.
Confidence score:

0.7548
Other information
Title:

Circ_0001944 Contributes to Glycolysis and Tumor Growth by Upregulating NFAT5 Through Acting as a Decoy for miR-142-5p in Non-Small Cell Lung Cancer.

Journal: Cancer management and research
Published: 2021
PubMed ID: 34040437
Study type:

combined biological and clinical study
Data availability: -
Code availability: -