| Expression pattern: |
UP |
| Associated gene: |
Ago2 |
| Associated microRNA: |
miR-126 |
| Biological function: |
promotes viability, migration and invasion and inhibits apoptosis in PTC cells; promotes tumor growth in vivo |
| Molecular mechanism: |
circPVT1 acts as a miRNA sponge (decoy) for miR-126; miR-126 inhibition rescues circPVT1-knockdown phenotypes |
| Biological pathway or process: |
proliferation (promotes); apoptosis (inhibits); migration (promotes); invasion (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Survival Analysis; Transfection; MTT; Annexin V/PI Flow Cytometry; Transwell Assay; Western Blot; Bioinformatics Analysis; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); In Vivo Animal Model |
| Clinical significance: |
High expression of circPVT1 was associated with poor outcomes of patients; high circPVT1 group displayed relative lower survival than low expression group |
| Description: |
circPVT1 is up-regulated in papillary thyroid carcinoma and its high expression correlates with worse overall survival. Functionally, circPVT1 promotes PTC cell viability, migration and invasion while inhibiting apoptosis, at least partly by sponging miR-126; circPVT1 knockdown suppresses xenograft tumor growth. |
| Confidence score: |
0.7548 |