| Expression pattern: |
UP |
| Associated gene: |
- |
| Associated microRNA: |
hsa-miR-637 |
| Biological function: |
May contribute to essential hypertension and endothelial cell injury; associated with LDL and serum creatinine levels. |
| Molecular mechanism: |
Bioinformatics/microarray suggested regulation of hsa-miR-637 by hsa_circ_0037909; ceRNA mechanism is discussed but downstream mRNA targets are not established in this study. |
| Biological pathway or process: |
ceRNA regulation (other); immune regulation (other) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis |
| Clinical significance: |
Potential biomarker for early diagnosis of EH; ROC AUC improved when combined with hsa-miR-637. |
| Description: |
hsa_circ_0037909 is up-regulated in essential hypertension patient blood and in TNF-alpha-treated endothelial cells, and is inversely associated with hsa-miR-637. The study suggests a circRNA/miRNA regulatory relationship and supports its potential as an early diagnostic biomarker (especially combined with hsa-miR-637), with correlations to LDL and serum creatinine. |
| Confidence score: |
0.5047 |