| Expression pattern: |
UP |
| Associated gene: |
UBQLN1, GPX4, YBX1 |
| Associated microRNA: |
- |
| Biological function: |
Promotes sorafenib resistance by regulating intracellular ROS levels and inhibiting ferroptosis; maintains mitochondrial integrity and redox homeostasis. |
| Molecular mechanism: |
Binds and stabilizes UBQLN1 to prevent its proteasomal degradation; UBQLN1 stabilizes GPX4 (STI-domain dependent), inhibiting GPX4 proteasomal degradation and suppressing ferroptosis under sorafenib-induced oxidative stress. |
| Biological pathway or process: |
ferroptosis (inhibits); mitochondrial function (promotes); oxidative phosphorylation (other); drug resistance (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Transfection; Western Blot; Flow Cytometry（Non-apoptosis/cycle）; In Vivo Animal Model; Bioinformatics Analysis; RNA Pull-Down; RIP (RNA Immunoprecipitation); Co-IP; IF (Immunofluorescence) |
| Clinical significance: |
- |
| Description: |
circRNA-SORE is up-regulated in sorafenib-resistant HCC cells and promotes drug resistance by reducing ROS and suppressing ferroptosis. It directly binds and stabilizes UBQLN1, which in turn stabilizes GPX4 and preserves redox/mitochondrial homeostasis under sorafenib-induced stress. |
| Confidence score: |
0.6562 |