| Expression pattern: |
DN |
| Associated gene: |
SOCS2 |
| Associated microRNA: |
miR-492 |
| Biological function: |
circ_0000526 functions as a tumor suppressor in breast cancer; it inhibits proliferation, migration, invasion, and metastasis of breast cancer cells and facilitates apoptosis. |
| Molecular mechanism: |
circ_0000526 acts as a sponge of miR-492 and indirectly enhances SOCS2 expression through the circ_0000526/miR-492/SOCS2 axis. |
| Biological pathway or process: |
proliferation (inhibits); migration (inhibits); invasion (inhibits); metastasis (inhibits); apoptosis (promotes); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; CCK8; Wound Healing Assay; Transwell Assay; Western Blot |
| Clinical significance: |
Low circ_0000526 expression was correlated with unfavorable pathological indexes and increased incidence of lymph node metastasis in breast cancer patients. |
| Description: |
circ_0000526 is down-regulated in breast cancer tissues and cell lines and acts as a tumor suppressor. Mechanistically, it sponges miR-492 and thereby indirectly increases SOCS2 expression, suppressing breast cancer cell proliferation, migration, invasion, and metastasis. Low circ_0000526 expression is associated with unfavorable clinicopathological features, including lymph node metastasis. |
| Confidence score: |
0.6521 |