circRNA basic information
circBase ID: hsa_circ_0001583
Name: hsa_circ_HIST1H1C
Synonym: circ_0001583
Host Gene: HIST1H1C
Genomic location(hg19): chr6:26056122-26056299:-
Genomic location(hg38): chr6:26055894-26056071:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007254
MONDO name: breast cancer
Disease details: breast cancer / BC
Disease DO ID:
 1612
Disease MeSH ID:
 -
Disease NCIt ID:
 C9335
Disease ICD11 ID:
 1047754165
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

breast cancer tissues; adjacent normal tissues
Cell lines:

MCF-7; MCF-10A
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: KPNA2
Associated microRNA: miR-93-5p, miR-6715a-3p, miR-17-5p
Biological function: promotes breast cancer cell proliferation
Molecular mechanism: ceRNA mechanism (predicted prognostic axes) involving miR-93-5p/miR-6715a-3p/miR-17-5p and KPNA2
Biological pathway or process:

proliferation (promotes); ceRNA regulation (other)
Detected method:
Q
M
Validation methods:

Microarray; Bioinformatics Analysis; RT-qPCR; Transfection; MTT; Colony Formation Assay; Survival Analysis
Clinical significance:

Upregulation of circ_0001583 predicts poor prognosis in breast cancer patients
Description:

circ_0001583 is up-regulated in breast cancer datasets and highly expressed in MCF-7 cells. Knockdown reduces MCF-7 proliferation, and the study proposes prognostic ceRNA axes linking circ_0001583 to KPNA2 via miR-93-5p, miR-6715a-3p, and miR-17-5p, associated with poor prognosis.
Confidence score:

0.5923
Other information
Title:

Upregulation of circ_0008812 and circ_0001583 predicts poor prognosis and promotes breast cancer proliferation.

Journal: Frontiers in molecular biosciences
Published: 2022
PubMed ID: 36200070
Study type:

combined biological and clinical study
Data availability: GSE165884; GSE182471; TCGA
Code availability: -