| Expression pattern: |
UP |
| Associated gene: |
premature miR-618 |
| Associated microRNA: |
miR-618 |
| Biological function: |
promotes CRC cell proliferation |
| Molecular mechanism: |
circ-ATAD1 binds premature miR-618 and suppresses miR-618 maturation (possibly by inhibiting nuclear-to-cytoplasm transport), thereby reducing mature miR-618 and promoting proliferation. |
| Biological pathway or process: |
proliferation (promotes); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Nuclear-Cytoplasmic Fractionation; RNA Pull-Down; Transfection; CCK8; Colony Formation Assay; Clinical Sample Validation; Cohort Study; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
high circ-ATAD1 levels were correlated to the poor survival of CRC patients |
| Description: |
circ-ATAD1 is up-regulated in colorectal cancer and promotes CRC cell proliferation. Mechanistically, it directly binds premature miR-618, suppressing miR-618 maturation (reduced mature miR-618), and high circ-ATAD1 expression is associated with worse overall survival. |
| Confidence score: |
0.7513 |