circRNA basic information
circBase ID: -
Name: hsa_circ_SATB2
Synonym: circSATB2
Host Gene: SATB2
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0021063
MONDO name: malignant colon neoplasm
Disease details: colon cancer
Disease DO ID:
 219
Disease MeSH ID:
 -
Disease NCIt ID:
 C9242
Disease ICD11 ID:
 1265576634
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

fresh-frozen tumor tissue / primary colon tumors
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UN
Associated gene: -
Associated microRNA: -
Biological function: Associated with MSI and CMS in stage I-II colon cancer.
Molecular mechanism: Not specified in this study (junction validated; clinical subtype association reported).
Biological pathway or process:

not specified
Detected method:
S
Validation methods:

RNA-seq; Sanger Sequencing; Clinical Sample Validation; Cohort Study; Bioinformatics Analysis
Clinical significance:

Presence/absence of circSATB2 is associated with MSI and CMS subtypes in stage I-II colon cancer.
Description:

In a cohort of 181 chemonaive stage I-II colon cancer tumors, circSATB2 presence/absence was associated with microsatellite instability status and consensus molecular subtypes. Its back-splice junction was supported by RNA-seq and validated by Sanger sequencing.
Confidence score:

0.559
Other information
Title:

Circular RNA in Chemonaive Lymph Node Negative Colon Cancer Patients.

Journal: Cancers
Published: 2021
PubMed ID: 33920880
Study type:

combined biological and clinical study
Data availability: The data that support the findings of this study are available on request from the corresponding author.
Code availability: -