| Expression pattern: |
UP |
| Associated gene: |
c-Myc, Ago2 |
| Associated microRNA: |
miR-1294 |
| Biological function: |
Promotes osteosarcoma progression, including proliferation, colony formation, migration, invasion, and tumor growth. |
| Molecular mechanism: |
Acts as a ceRNA sponge for miR-1294 to upregulate c-Myc expression. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); metastasis (other); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Bioinformatics Analysis; RT-qPCR; Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Sanger Sequencing; FISH / smFISH; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Transfection; CCK8; EdU Staining; Colony Formation Assay; Transwell Assay; Wound Healing Assay; Western Blot; IHC (Immunohistochemistry); In Vivo Animal Model; Clinical Sample Validation; Microarray |
| Clinical significance: |
- |
| Description: |
circOMA1 (hsa_circ_0002316), derived from OMA1, is up-regulated in osteosarcoma tissues and cell lines and mainly localizes to the cytoplasm. It promotes osteosarcoma malignant phenotypes and tumor growth by sponging miR-1294, thereby increasing c-Myc expression (circOMA1/miR-1294/c-Myc axis). |
| Confidence score: |
0.8635 |