| Expression pattern: |
UP |
| Associated gene: |
LASP1 |
| Associated microRNA: |
miR-579 |
| Biological function: |
Promotes OSCC cell proliferation, migration, invasion and EMT, and inhibits apoptosis. |
| Molecular mechanism: |
Acts as a ceRNA by sponging miR-579 to regulate LASP1 expression (circBCL11B/miR-579/LASP1 axis). |
| Biological pathway or process: |
proliferation (promotes); apoptosis (inhibits); migration (promotes); invasion (promotes); EMT (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; Survival Analysis; Transfection; CCK8; Colony Formation Assay; EdU Staining; Annexin V/PI Flow Cytometry; Transwell Assay; Western Blot; Luciferase Reporter Assay; RNA Pull-Down; Bioinformatics Analysis |
| Clinical significance: |
High circBCL11B expression was associated with shorter overall survival and correlated with tumor size, TNM stage, and distal metastasis. |
| Description: |
circBCL11B (hsa_circ_0033144) is up-regulated in OSCC tissues and cell lines, mainly localized in the cytoplasm, and its high expression is associated with worse overall survival and more aggressive clinicopathologic features. Functionally, circBCL11B promotes proliferation, migration/invasion and EMT while suppressing apoptosis. Mechanistically, circBCL11B acts as a ceRNA for miR-579 to de-repress LASP1 (circBCL11B/miR-579/LASP1 axis). |
| Confidence score: |
0.8174 |