| Expression pattern: |
UP |
| Associated gene: |
VEGFA |
| Associated microRNA: |
hsa-miR-106b-5p |
| Biological function: |
promotes proliferation, migration and invasion of COAD cells; associated with poor prognosis; potential circulating diagnostic marker |
| Molecular mechanism: |
ceRNA mechanism: hsa_circ_0084927 sponges hsa-miR-106b-5p and is associated with VEGFA regulation |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); cell cycle (other); apoptosis (other); Wnt/beta-catenin (other); ceRNA regulation (promotes) |
| Detected method: |
Q
S
|
| Validation methods: |
RNA-seq; RT-qPCR; Clinical Sample Validation; ROC Analysis; Survival Analysis; Cohort Study; Transfection; CCK8; Transwell Assay; Wound Healing Assay; Bioinformatics Analysis |
| Clinical significance: |
Plasma hsa_circ_0084927 is up-regulated in COAD patients and shows diagnostic value (AUC=0.78); high hsa_circ_0084927 expression is an independent risk factor for poor OS in COAD patients |
| Description: |
hsa_circ_0084927 is up-regulated in COAD tissues, cell lines, and patient plasma and promotes COAD cell proliferation, migration, and invasion. It is proposed to act via a ceRNA axis involving hsa-miR-106b-5p and VEGFA, and higher expression is associated with poorer overall survival and diagnostic potential in plasma. |
| Confidence score: |
0.7173 |