circRNA basic information
circBase ID: hsa_circ_0007144
Name: hsa_circ_PTPRM
Synonym: circRNA PTPRM / circPTPRM
Host Gene: PTPRM
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005233
MONDO name: non-small cell lung carcinoma
Disease details: non-small cell lung cancer / NSCLC
Disease DO ID:
 3908
Disease MeSH ID:
 D002289
Disease NCIt ID:
 C2926
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

NSCLC tissue samples; adjacent normal tissues; tumor tissues
Cell lines:

16HBE; A549; H1299; PC-9; H1975
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: SETD5
Associated microRNA: miR-139-5p
Biological function: promotes NSCLC progression and tumor growth; promotes proliferation, migration, invasion; inhibits apoptosis
Molecular mechanism: Acts as a ceRNA (miRNA sponge) for miR-139-5p to regulate SETD5.
Biological pathway or process:

ceRNA regulation (promotes); proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; RNA Pull-Down; Transfection; CCK8; EdU Staining; Transwell Assay; Annexin V/PI Flow Cytometry; In Vivo Animal Model; Western Blot; IHC (Immunohistochemistry)
Clinical significance:

-
Description:

circPTPRM is up-regulated in NSCLC tissues and cell lines and promotes NSCLC proliferation, migration, invasion and tumor growth while suppressing apoptosis. Mechanistically, circPTPRM functions as a ceRNA by sponging miR-139-5p, thereby relieving repression of SETD5 (circPTPRM/miR-139-5p/SETD5 axis).
Confidence score:

0.7552
Other information
Title:

CircRNA PTPRM Promotes Non-Small Cell Lung Cancer Progression by Modulating the miR-139-5p/SETD5 Axis.

Journal: Technology in cancer research & treatment
Published: 2022
PubMed ID: 35491723
Study type:

combined biological and clinical study
Data availability: Supplemental material for this article is available online.
Code availability: -