| Expression pattern: |
DN |
| Associated gene: |
FOXO3 |
| Associated microRNA: |
miR-570-3p |
| Biological function: |
circ_0005927 acts as a tumor suppressor in gastric cancer by inhibiting GC cell proliferation, colony formation, invasion and EMT. |
| Molecular mechanism: |
circ_0005927 functions through a ceRNA mechanism by sequestering miR-570-3p, thereby upregulating FOXO3 expression. |
| Biological pathway or process: |
proliferation (inhibits); invasion (inhibits); EMT (inhibits); metastasis (inhibits); ceRNA regulation (other) |
| Detected method: |
Q
M
|
| Validation methods: |
RNase R Treatment; RT-qPCR; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; Luciferase Reporter Assay; Transfection; MTT; Colony Formation Assay; Transwell Assay; Western Blot; ROC Analysis; Bioinformatics Analysis |
| Clinical significance: |
Low circ_0005927 expression was associated with poor prognosis in GC patients and circ_0005927 showed diagnostic potential for GC. |
| Description: |
circ_0005927 is downregulated in gastric cancer tissues and cell lines and is associated with diagnostic potential and prognosis. Functionally, circ_0005927 suppresses GC cell proliferation, colony formation, invasion and EMT by acting as a ceRNA for miR-570-3p to upregulate FOXO3. |
| Confidence score: |
0.7846 |