circRNA basic information
circBase ID: -
Name: hsa_circ_CRIM1
Synonym: circCRIM1
Host Gene: CRIM1
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0015459
MONDO name: nasopharyngeal carcinoma
Disease details: nasopharyngeal carcinoma / NPC
Disease DO ID:
 9261
Disease MeSH ID:
 D00007727; D000077274
Disease NCIt ID:
 C3871
Disease ICD11 ID:
 1883313543
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

-
Cell lines:

NP69; SUNE-1; CNE2; C666-1; CNE-1; HNE1; 5-8F
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: FOSL1
Associated microRNA: miR-34c-5p
Biological function: promotes NPC cell proliferation, viability, migration and invasion; silencing circCRIM1 inhibits NPC tumorigenesis
Molecular mechanism: circCRIM1 binds (sponges) miR-34c-5p, thereby relieving miR-34c-5p-mediated repression of downstream target FOSL1
Biological pathway or process:

proliferation (promotes); migration (promotes); invasion (promotes); ceRNA regulation (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; Luciferase Reporter Assay; Transfection; MTT; Transwell Assay; Western Blot
Clinical significance:

-
Description:

circCRIM1 is up-regulated in NPC cell lines and promotes malignant phenotypes (viability/proliferation, migration, invasion). Mechanistically, circCRIM1 binds miR-34c-5p and increases the downstream target FOSL1, forming a circCRIM1/miR-34c-5p/FOSL1 regulatory axis.
Confidence score:

0.5223
Other information
Title:

CircCRIM1 promotes nasopharyngeal carcinoma progression via the miR-34c-5p/FOSL1 axis.

Journal: European journal of medical research
Published: 2022
PubMed ID: 35484574
Study type:

biological research
Data availability: -
Code availability: -