| Expression pattern: |
UP |
| Associated gene: |
methylene blue |
| Associated microRNA: |
- |
| Biological function: |
Potential biomarker/marker for detecting early stages of HCC; used as a detection target in a PCR-free electrochemical biosensor. |
| Molecular mechanism: |
Detection based on specific back-splice junction (BSJ) capture probe hybridization and electrochemical readout using methylene blue redox signal on AuNPs-SPME. |
| Biological pathway or process: |
not specified |
| Detected method: |
M
|
| Validation methods: |
Bioinformatics Analysis; Microarray |
| Clinical significance: |
Specifically up regulated and an independent marker for detecting early stages of HCC; detection verified in human serum samples for potential clinical diagnosis. |
| Description: |
The study develops a PCR-free electrochemical biosensor to detect circCDYL via BSJ-targeting capture probes and methylene-blue DPV readout, and verifies performance in human serum. circCDYL is described as specifically up-regulated in HCC and an independent marker for early-stage HCC detection. |
| Confidence score: |
0.1768 |