| Expression pattern: |
UP |
| Associated gene: |
TP53INP2, OSTM1, KMT2D |
| Associated microRNA: |
miR‐874‐3p, miR‐487‐5p |
| Biological function: |
promotes cell proliferation and migration; inhibits apoptosis in ESCC cells |
| Molecular mechanism: |
acts as a miRNA sponge (ceRNA) binding miR-874-3p (also reported binding miR-487-5p); potentially modulates downstream targets including TP53INP2 and KMT2D |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); apoptosis (inhibits); ceRNA regulation (promotes); Hippo/YAP (other) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis; Transfection; CCK8; Colony Formation Assay; Transwell Assay; Wound Healing Assay; Annexin V/PI Flow Cytometry; Luciferase Reporter Assay |
| Clinical significance: |
hsa_circ_0000977 is higher in ESCC plasma and shows diagnostic value (AUC 0.9888); its expression is associated with pT stage and number of positive lymph nodes and may be used for outcome prediction |
| Description: |
In ESCC, hsa_circ_0000977 is up-regulated in patient plasma and shows strong diagnostic performance by ROC analysis. Functionally, it promotes ESCC cell proliferation and migration and inhibits apoptosis, at least partly by acting as a miRNA sponge (binding miR-874-3p) and potentially affecting downstream targets such as TP53INP2 and KMT2D. |
| Confidence score: |
0.7369 |