| Expression pattern: |
DN |
| Associated gene: |
PI3K, AKT, Wnt3a, Wnt5a, beta-catenin |
| Associated microRNA: |
miR-665 |
| Biological function: |
CircRNA-0072309 acts as a tumor suppressor in liver cancer by inhibiting Hep3B cell viability, colony formation, migration and invasion, while promoting apoptosis. |
| Molecular mechanism: |
CircRNA-0072309 targets and negatively regulates miR-665, leading to deactivation of PI3K/AKT and Wnt/beta-catenin pathways. |
| Biological pathway or process: |
PI3K/AKT (inhibits); Wnt/beta-catenin (inhibits); proliferation (inhibits); apoptosis (promotes); migration (inhibits); invasion (inhibits); EMT (inhibits); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; Annexin V/PI Flow Cytometry; Transwell Assay; Western Blot; Survival Analysis |
| Clinical significance: |
High expression level of circRNA-0072309 was associated with high 5-year survival rate of patients. |
| Description: |
CircRNA-0072309 is down-regulated in liver cancer tissues and HCC cell lines, and higher expression is associated with better 5-year survival. Functionally, it suppresses Hep3B cell viability, colony formation, migration and invasion while promoting apoptosis. Mechanistically, circRNA-0072309 targets miR-665 and deactivates PI3K/AKT and Wnt/beta-catenin signaling pathways. |
| Confidence score: |
0.7126 |