| Expression pattern: |
DS |
| Associated gene: |
EIF4A3 |
| Associated microRNA: |
- |
| Biological function: |
Associated with gastric cancer and decreases in serum after curative surgery, supporting tumor-specific circulating biomarker potential. |
| Molecular mechanism: |
Not mechanistically characterized in this study; discussed as potentially interacting with RNA binding protein EIF4A3 as part of the panel. |
| Biological pathway or process: |
not specified |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; RNase R Treatment; divergent primers PCR; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis |
| Clinical significance: |
Part of an 8-circRNA serum biomarker panel that discriminated GC from non-disease controls and decreased post-surgery, supporting noninvasive early detection utility. |
| Description: |
hsa_circ_0045602 is one component of an 8-circRNA serum panel derived from GC tissue discovery and validated by RT-qPCR in tissues and serum cohorts. The panel shows diagnostic ability for GC and marker levels decrease after curative surgery, supporting a tumor-associated circulating biomarker role. |
| Confidence score: |
0.6556 |