circRNA basic information
circBase ID: -
Name: hsa_circ_CDR1
Synonym: ciRS-7 / CDR1
Host Gene: CDR1
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005083
MONDO name: psoriasis
Disease details: psoriasis
Disease DO ID:
 8893
Disease MeSH ID:
 D011565
Disease NCIt ID:
 C3346
Disease ICD11 ID:
 63698555
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

skin biopsies; lesional skin; non-lesional skin
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: -
Associated microRNA: -
Biological function: Biomarker potential (correlates with PASI); exhibits compartment-specific expression changes in epidermis vs dermis during treatment.
Molecular mechanism: not specified
Biological pathway or process:

not specified
Detected method:
H
Validation methods:

Microarray; ISH (In Situ Hybridization); Clinical Sample Validation; Bioinformatics Analysis
Clinical significance:

Correlates negatively with PASI; suggested biomarker potential for disease severity and post-treatment disease resolution.
Description:

ciRS-7 is reduced in the epidermis of psoriatic lesional skin at baseline and is strongly upregulated during secukinumab therapy, with spatial redistribution/normalization across epidermis and dermis. Its expression negatively correlates with PASI, indicating potential as a severity/response biomarker in skin.
Confidence score:

0.4032
Other information
Title:

Global circRNA expression changes predate clinical and histological improvements of psoriasis patients upon secukinumab treatment.

Journal: PloS one
Published: 2022
PubMed ID: 36174034
Study type:

combined biological and clinical study
Data availability: S1 File; S2 File; S3 File; S4 File
Code availability: -