| Expression pattern: |
UP |
| Associated gene: |
PDK1, pyruvate dehydrogenase kinase 1 |
| Associated microRNA: |
miR-152-3p |
| Biological function: |
Facilitates ICC cell proliferation, invasion, migration, glycolysis and tumor growth, and inhibits apoptosis. |
| Molecular mechanism: |
circ_0000284 acts as a ceRNA sponge for miR-152-3p to upregulate PDK1 expression, promoting ICC growth, metastasis and glycolysis. |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (promotes); apoptosis (inhibits); migration (promotes); invasion (promotes); metastasis (promotes); glycolysis (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RNase R Treatment; RT-qPCR; Clinical Sample Validation; Nuclear-Cytoplasmic Fractionation; Transfection; CCK8; EdU Staining; Annexin V/PI Flow Cytometry; Transwell Assay; Wound Healing Assay; Western Blot; Luciferase Reporter Assay; Bioinformatics Analysis; IHC (Immunohistochemistry); In Vivo Animal Model; H&E Staining; Survival Analysis; Cohort Study |
| Clinical significance: |
High circ_0000284 expression was associated with lower overall survival rate and lymph node metastasis in ICC patients. |
| Description: |
circ_0000284 is up-regulated in ICC tissues and cells and is associated with lymph node metastasis and poorer overall survival. Functionally, it promotes ICC proliferation, invasion, migration, glycolysis and xenograft tumor growth while suppressing apoptosis. Mechanistically, circ_0000284 acts as a cytoplasmic ceRNA sponge for miR-152-3p, thereby increasing PDK1 expression and driving ICC malignant progression. |
| Confidence score: |
0.8157 |