| Expression pattern: |
DN |
| Associated gene: |
CDK4, cyclin D, cyclin E, MMP9 |
| Associated microRNA: |
- |
| Biological function: |
Inhibits colorectal cancer cell proliferation and migration; knockdown promotes colony formation. |
| Molecular mechanism: |
Knockdown increases CDK4, cyclin D, cyclin E and MMP9 (mRNA/protein), suggesting regulation of cell-cycle and migration-related factors; ceRNA/miRNA and protein-binding mechanisms were not assessed. |
| Biological pathway or process: |
proliferation (inhibits); migration (inhibits); cell cycle (inhibits) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Transfection; CCK8; Colony Formation Assay; Wound Healing Assay; Western Blot; Clinical Sample Validation |
| Clinical significance: |
May act as a potential novel molecular diagnostic marker for CRC (limited by small sample size). |
| Description: |
hsa_circ_0001696 is down-regulated in colorectal cancer tissues. Functionally, its knockdown promotes CRC cell proliferation, colony formation, and migration, accompanied by increased CDK4/cyclin D/cyclin E and MMP9 levels, suggesting a tumor-suppressive role. |
| Confidence score: |
0.5414 |