| Expression pattern: |
DN |
| Associated gene: |
STARD13 |
| Associated microRNA: |
miR-182-5p |
| Biological function: |
Suppresses HCC cell proliferation, migration, invasion; represses tumor growth and lung metastasis in vivo. |
| Molecular mechanism: |
Acts as a competing endogenous RNA (miRNA sponge) that binds miR-182-5p to relieve repression of STARD13. |
| Biological pathway or process: |
proliferation (inhibits); migration (inhibits); invasion (inhibits); metastasis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Transfection; MTT; Colony Formation Assay; Transwell Assay; Wound Healing Assay; Luciferase Reporter Assay; Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry); H&E Staining; Bioinformatics Analysis |
| Clinical significance: |
- |
| Description: |
circ_0003570 is down-regulated in HCC cell lines and acts as a tumor suppressor. It sponges miR-182-5p to de-repress STARD13, thereby inhibiting proliferation, migration, invasion and metastasis of HCC cells in vitro and in vivo. |
| Confidence score: |
0.6544 |