| Expression pattern: |
DN |
| Associated gene: |
PPM1L, PKR |
| Associated microRNA: |
miR-661 |
| Biological function: |
inhibits proliferation; inhibits migration; inhibits invasion; inhibits metastasis; represses EMT |
| Molecular mechanism: |
ceRNA sponging of miR-661 to restore PPM1L expression; binds PKR and promotes ubiquitin/proteasome-dependent degradation of PKR, regulating p38 MAPK signaling and EMT |
| Biological pathway or process: |
proliferation (inhibits); migration (inhibits); invasion (inhibits); metastasis (inhibits); EMT (inhibits); MAPK (inhibits); ubiquitination (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; Bioinformatics Analysis; RT-qPCR; Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; RNase R Treatment; Actinomycin D / DRB Stability Assay; Nuclear-Cytoplasmic Fractionation; FISH / smFISH; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; RNA Pull-Down; Western Blot; Co-IP; Transfection; CCK8; Colony Formation Assay; EdU Staining; Transwell Assay; In Vivo Animal Model; H&E Staining; IHC (Immunohistochemistry); Clinical Sample Validation; Cohort Study; Survival Analysis |
| Clinical significance: |
circFAM120B was frequently downregulated in cancer tissues and patient plasma, and its expression level was related to overall survival in ESCC patients. |
| Description: |
circFAM120B (hsa_circ_0001666) is down-regulated in ESCC tissues and patient plasma and higher expression indicates better overall survival. It suppresses ESCC proliferation/migration/invasion/metastasis by sponging miR-661 to restore PPM1L expression and by binding PKR to promote its ubiquitin/proteasome-dependent degradation, thereby inhibiting p38 MAPK signaling and EMT. |
| Confidence score: |
0.9018 |