| Expression pattern: |
UP |
| Associated gene: |
MCUR1, Ago2, P-gp, MDR1, ABCB1 |
| Associated microRNA: |
miR-383 |
| Biological function: |
promotes HCC cell proliferation, migration and invasion; accelerates cell cycle progression; inhibits apoptosis; promotes HCC progression in vivo; promotes doxorubicin resistance |
| Molecular mechanism: |
acts as a miRNA sponge to sequester miR-383, thereby relieving repression of MCUR1 (via MCUR1 3'-UTR) and increasing MCUR1 expression; increases ATP levels and P-gp expression contributing to doxorubicin efflux and resistance |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); cell cycle (promotes); apoptosis (inhibits); chemoresistance (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RNase R Treatment; divergent primers PCR; RT-qPCR; Sanger Sequencing; FISH / smFISH; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; ROC Analysis; Survival Analysis; Bioinformatics Analysis; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; Transwell Assay; Cell Cycle Assay; Annexin V/PI Flow Cytometry; Western Blot; In Vivo Animal Model; H&E Staining; IHC (Immunohistochemistry) |
| Clinical significance: |
circ_0000098 functioned as a potential diagnostic tumor marker in HCC (AUC = 0.829); high circ_0000098 expression associated with shorter survival |
| Description: |
circ_0000098 is up-regulated in HCC and acts as an oncogenic circRNA. It mainly localizes in the cytoplasm and promotes HCC progression and doxorubicin resistance by sponging miR-383 to increase MCUR1, leading to higher ATP levels and P-gp-mediated drug efflux. Clinically, higher circ_0000098 associates with worse survival and shows diagnostic potential (ROC AUC 0.829). |
| Confidence score: |
0.8824 |