| Expression pattern: |
DN |
| Associated gene: |
LATS1, YAP, TAZ |
| Associated microRNA: |
miR-183-5p |
| Biological function: |
Inhibits LUAD cell proliferation, viability, migration, invasion and angiogenesis; promotes apoptosis. |
| Molecular mechanism: |
Acts as a miRNA sponge for miR-183-5p to up-regulate LATS1 and activate the Hippo/YAP pathway. |
| Biological pathway or process: |
Hippo/YAP (promotes); proliferation (inhibits); migration (inhibits); invasion (inhibits); angiogenesis (inhibits); apoptosis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; MTT; Colony Formation Assay; Annexin V/PI Flow Cytometry; Transwell Assay; Tube Formation Assay; Luciferase Reporter Assay; Western Blot; Bioinformatics Analysis |
| Clinical significance: |
circ_0067741/miR-183-5p/LATS1 axis can be a potential target for early diagnosis and targeted treatment of LUAD. |
| Description: |
circ_0067741 is down-regulated in LUAD tissues and cell lines and functions as a tumor suppressor. It sponges miR-183-5p to increase LATS1, thereby activating Hippo/YAP signaling (increasing p-YAP and reducing YAP/TAZ activity) and inhibiting malignant phenotypes. |
| Confidence score: |
0.6542 |